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BPS Bioscience的PROTAC和蛋白質(zhì)降解研究服務(wù)
- 公司名稱 BPS Bioscience Inc.
- 品牌 BPS Bioscience
- 型號(hào)
- 產(chǎn)地
- 廠商性質(zhì) 生產(chǎn)廠家
- 更新時(shí)間 2023/12/19 23:38:49
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BPS Bioscience是一家通過(guò)ISO 9001:2015認(rèn)證的生命科學(xué)領(lǐng)域的供應(yīng)商，公司一直致力于開發(fā)藥物研發(fā)領(lǐng)域的重組蛋白、檢測(cè)試劑盒、細(xì)胞系和慢病毒等工具。公司由Henry Zhu博士于2005年創(chuàng)立，從創(chuàng)立至今一直致力于提供藥物研發(fā)領(lǐng)域的創(chuàng)新解決方案，以推動(dòng)新的藥物發(fā)現(xiàn)。公司主要關(guān)注的領(lǐng)域包括免疫療法、表觀遺傳學(xué)、病毒工具、CRISPR、細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)等，BPS提供超過(guò)4500種高質(zhì)量研究工具，其中包括100多種特色產(chǎn)品。
BPS Bioscience一直保持在新品研發(fā)上的投入，公司平均每月推出20多種新產(chǎn)品。BPS Bioscience除了可以穩(wěn)定供應(yīng)現(xiàn)貨產(chǎn)品外，也可接受客戶的多樣化的產(chǎn)品定制要求。此外，BPS Bioscience專業(yè)的技術(shù)團(tuán)隊(duì)也提供所專注領(lǐng)域的生化和以細(xì)胞為基礎(chǔ)的檢測(cè)和化合物篩選服務(wù)。
BPS Bioscience成立之初主要提供市面上較為極少商業(yè)化的難以制造的重組蛋白、表觀遺傳學(xué)和細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)相關(guān)的蛋白復(fù)合物。
隨后，這些功能性蛋白被用于多種檢測(cè)試劑盒的開發(fā)，現(xiàn)在BPS Bioscience提供包括化學(xué)發(fā)光、比色、熒光、TR-FRET、熒光偏振和AlphaLISA ® 在內(nèi)的多種檢測(cè)試劑盒。目前，公司已將產(chǎn)品線延伸至到重組細(xì)胞系和慢病毒工具，以期進(jìn)一步促進(jìn)生化和細(xì)胞學(xué)研究。
2021 年，為了進(jìn)一步完善實(shí)驗(yàn)室設(shè)施，BPS Bioscience 搬遷至位于加利福尼亞州圣地亞哥索倫托-梅薩生物技術(shù)中心區(qū)的 38,000 平方英尺的新實(shí)驗(yàn)室，。
BPS Bioscience 的座口號(hào)是“科學(xué)家創(chuàng)立，科學(xué)家驅(qū)動(dòng)”，公司一直致力于在滿足科學(xué)界不斷發(fā)展的需求。
BPS Bioscience 的使命是通過(guò)提供創(chuàng)新的解決方案來(lái)推進(jìn)新的科學(xué)發(fā)現(xiàn)，推動(dòng)新的治療方法的面世。
我們專注于滿足新興研究需求，并以最快速度提供最新的解決方案。
BPS Bioscience專注于開發(fā)高質(zhì)量的產(chǎn)品，提供優(yōu)質(zhì)的客戶服務(wù)，并維護(hù)穩(wěn)健的質(zhì)量管理體系。BPS Bioscience現(xiàn)已通過(guò)ISO 9001:2015認(rèn)證，確保質(zhì)量的持續(xù)監(jiān)控和持續(xù)改進(jìn)，從而滿足客戶需求。
BPS Bioscience產(chǎn)品涉及臨床前藥物開發(fā)過(guò)程的每個(gè)階段。其中部分產(chǎn)品可以用于許多研究階段。BPS Bioscience將繼續(xù)豐富我們的產(chǎn)品線，希望以此推動(dòng)了整個(gè)早期藥物研發(fā)過(guò)程。
生物試劑
- 服務(wù)名稱：
PROTAC和蛋白質(zhì)降解研究服務(wù)
BPS Bioscience is a leading product manufacturer and service provider in the PROTAC space. Using our services, we can design and conduct homogeneous proximity assays to assess the chemical adaptor function of PROTACs.
BPS Bioscience has designed many assays to measure and study
Cereblon Binding
Cereblon Ubiquitination
PROTAC Optimization for BET Bromodomain-Cereblon Binding
PROTAC Optimization for BET Bromodomain-Von Hippel Lindau (VHL) Binding
PROTAC Optimization for CDK Kinase-Cereblon Binding
In addition to our existing assay portfolio, we have the capabilities to develop custom PROTAC and Protein Degradation assays specialized for your project details. Please contact us to learn more.
Example Assay
The PROTAC Optimization Assay for BET Bromodomain-Cereblon Binding is designed for testing and profiling of PROTACs directed against BET Bromodomain family and Cereblon complex. Cereblon (CRBN) is a Substrate recognition component of a DCX (DDB1-CUL44-Rbx1 ) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
With this assay, only three simple steps on a microtiter plate are required for PROTAC activity detection. First, a sample containing PROTAC is incubated with CRBN and BRD3(BD2), one of BET bromodomains. Next, acceptor beads are added, then donor beads, followed by reading the Alpha-counts.
Inhibition by (+)-JQ1 (BPS Bioscience #27401) or Pomalidomide of dBET1-mediated interaction of Cereblon with BRD3(BD2), measured using the PROTAC Optimization Kit for BET Bromodomain Cereblon Binding, BPS Bioscience #79770.
PROTACs ®
Targeted protein degradation using Proteolysis Targeting Chimeras, or PROTAC , is a new and promising therapeutic method in drug discovery. PROTACs have the ability to regulate protein degradation through targeted control of ubiquitin E3 ligases. This novel technology allows for the degradation of disease-related proteins and offers many advantages over traditional protein inhibition.
PROTACs function by hijacking the final action of E3 ligases and subsequently tagging the protein of interest for ubiquitination. A PROTAC is composed of three parts; an E3 ligａnd that binds to an E3 ligase, a ligａnd that binds to the protein of interest, and a linker connecting the two ligands. When each ligａnd binds its respective partner, it triggers ubiquitination of the protein of interest. The PROTAC itself is not degraded by this process, making PROTACs a valuable tool for mediating protein degradation. A single PROTAC can promote the degradation of many subsequent proteins and functions substoichiometrically.
Advantages
Promotes degradation that circumvents the native resistance of proteins against sustained inhibition
Select weak binding and promiscuous ligands can be utilized with PROTACs and still demonstrate high degradation efficacy
Ineffectual ligands which do not modulate the cellular functions of the protein of interest can be used to mediate degradation through PROTACs
PROTACs could have the ability to degrade proteins previously believed to be 'undruggable' through conventional small molecule inhibition
PROTAC ® is a registered trademark of Arvinas Operations Inc., and is used under license
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