點(diǎn)擊化學(xué)利用四嗪碳納米管實(shí)現(xiàn)靶向成像

利用TCO和Tz之間的正交切割反應(yīng)，把Tz搭載于靶向性的納米材料單壁碳納米管SWCNTs上（Tz@SWCNTs），實(shí)現(xiàn)對(duì)預(yù)靶向。其主要原理：利用通透性增與滯留效應(yīng)，使Tz@SWCNTs在組織中積累。通過TCO分子或探針，由在富集的Tz進(jìn)行正交切割。

通過研究tAMC與Tz@SWCNTs之間的釋放動(dòng)力學(xué)，相比于mTZ小分子，Tz@SWCNTs對(duì)tAMC的衰減反應(yīng)性，且能在下，對(duì)MCF-7進(jìn)行靶向并tAMC熒光。

將陽離子染料半菁HCA和TCO相連得到近紅外熒光探針tHCA用于通過生物正交釋放反應(yīng)的近紅外熒光探針。該探針在下因Tz@SWCNTs的激發(fā)釋放，并在720nm下發(fā)出熒光。

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