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BioXcell：InVivoMAb anti-mouse CSF1R (CD115)
閱讀：578 發(fā)布時間：2022-8-1
一、 產(chǎn)品介紹
落刺激因子1受體(CSF1R)，也稱為巨噬細胞集落刺激因子受體(M-CSFR)，即CD115反應(yīng)。CSF1R是一種單程I型膜蛋白，是血小板衍生生長因子受體家族的成員。在小鼠中，CSF1R由單核細胞/巨噬細胞、腹膜滲出物細胞、漿細胞樣和常規(guī)樹突細胞以及破骨細胞表達。CSF1R是CSF1的受體，CSF1R通過CSF1R調(diào)節(jié)單核細胞譜系中細胞的增殖和分化。據(jù)報道，克隆號AFS98抗體可在體內(nèi)deplete巨噬細胞并阻斷CSFR1。
二 、產(chǎn)品詳情
| 產(chǎn)品詳情 | |
| 產(chǎn)品貨號 | BE0213 |
| 產(chǎn)品規(guī)格 | 1/5/25/50/100mg |
| 抗體亞型 | Rat IgG2a, κ |
| 推薦同型對照 | InVivoMAb rat IgG2a isotype control, anti-trinitrophenol（貨號：BE0089） |
| 推薦抗體稀釋液 | InVivoPure™ pH 7.0 Dilution Buffer（貨號：IP0070） |
| 免疫原 | Not available or unknown |
| 應(yīng)用 | in vivo macrophage depletion/in vitro CSF1R neutralization/in vivo monocyte depletion/Flow cytometry/Western blot |
| 產(chǎn)品形式 | PBS , pH 7.0 Contains no stabilizers or preservatives |
| 內(nèi)毒素水平 | <2EU/mg (<0.002EU/μg) 使用 LAL gel clotting 測定 |
| 純度 | >95% Determined by SDS-PAGE |
| 無菌處理 | 0.2 μM filtered |
| 生產(chǎn)形式 | 從組織培養(yǎng)上清液中純化得到。 |
| 純化形式 | Protein G |
| RRID | AB_2687699 |
| 分子量大小 | 150 kDa |
| 保存條件 | 抗體原溶液應(yīng)保存在4°C條件下，不要冷凍保存。 |
三 、已發(fā)表文獻
| 用途 | 已發(fā)表文獻 |
| in vivo macrophage depletion | Bauche, D., et al. (2018). “LAG3(+) Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1(+) Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis." Immunity 49(2): 342-352 e345 |
| in vivo macrophage depletion | Gordon, S. R., et al. (2017). “PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity." Nature 545(7655): 495-499 |
| in vivo macrophage depletion | Moynihan, K. D., et al. (2016). “Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses." Nat Med. doi: 10.1038/nm.4200 |
| in vivo macrophage depletion | Arnold, I. C., et al. (2015). “CD11c monocyte/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23." Mucosal Immunol. doi: 10.1038/mi.2015.65 |
| in vivo macrophage depletion | Kaminsky, L. W., et al. (2015). “Redundant Function of Plasmacytoid and Conventional Dendritic Cells Is Required To Survive a Natural Virus Infection." J Virol 89(19): 9974-9985 |
| in vivo monocyte depletion | Naik, S., et al. (2015). “Commensal-dendritic-cell interaction specifies a unique protective skin immune signature." Nature 520(7545): 104-108 |
| in vitro CSF-R1 neutralization | Sheng, K. C., et al. (2014). “IL-3 and CSF-1 interact to promote generation of CD11c+ IL-10-producing macrophages." PLoS One 9(4): e95208. |
| in vivo monocyte depletion | Greter, M., et al. (2012). “GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells." Immunity 36(6): 1031-1046. |
| in vivo macrophage depletion | Tagliani, E., et al. (2011). “Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1." J Exp Med 208(9): 1901-1916 |
| in vivo macrophage depletion | Lim, A. K., et al. (2009). “Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice." Diabetologia 52(8): 1669-1679. |
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