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08CON013-ω-Conotoxin-SO3 （ω-漏斗網(wǎng)蛛毒素SO3 ）
- 發(fā)布日期：
- 有效日期：
- 所 在 地：
- 產(chǎn) 地：
- 已獲點(diǎn)擊：
- 2025年4月24日
- 2025年10月24日
- 北京北京市
- 89次
【產(chǎn)品簡(jiǎn)介】
【詳細(xì)說明】
ω-Conotoxin-SO3 (ω-漏斗網(wǎng)蛛毒素SO3 )
Selective blocker of N-type calcium channels
N型鈣通道選擇性阻斷劑
ω-conotoxin SO-3 is a selective blocker of N-type voltage-sensitive calcium channels. EC50 for ω-conotoxin SO-3 is 0.16 µM (similar to ω-conotoxin MVIIA) on HVA calcium currents. ω-conotoxin SO-3 did not show any inhibiting effects on L-type, P/Q-type and R-type currents at 3 µM concentration. ω-conotoxin SO-3 has no effect on voltage-sensitive sodium currents, delayed rectifier potassium currents and transient outward potassium currents. At 3 µM, the inhibition amounts of HVA ICa was very similar between ω-conotoxin SO-3 and ω-conotoxin MVIIA (~ 32%). Their inhibitory effects are almost fully reversible but their half-time for recovery are different (~ 7.5 min for ω-conotoxin SO-3 and ~ 4.14 min for ω-conotoxin MVIIA). ω-conotoxin SO-3 displays an analgesic potency similar to ω-conotoxin MVIIA in a range of acute and chronic pain models in rodents, but has less adverse effects compared with identical dosages of ω-conotoxin MVIIA injected intrathecally.
ω-Conotoxin-SO3 (ω-漏斗網(wǎng)蛛毒素SO3 )技術(shù)資料
氨基酸序列：
Cys1-Lys-Ala-Ala-Gly-Lys-Pro-Cys8-Ser-Arg-Ile-Ala-Tyr-Asn-Cys15-Cys16-Thr-Gly-Ser-Cys20-Arg-Ser-Gly-Lys-Cys25-NH2
二硫鍵：Cys1-Cys16, Cys8-Cys20 and Cys15-Cys25
長(zhǎng)度 (aa)：25
分子式： C100H165N35O32S6
分子量： 2567.07 Da
外觀：White lyophilized solid
可溶性： water and saline buffer
CAS 號(hào)：not available
來源：Synthetic
純度：> 97 %
產(chǎn)品信息
08CON013-00100 | ω-conotoxin SO3(ω-漏斗網(wǎng)蛛毒素SO3 ) | 0.1mg |
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08CON013-00500 | ω-conotoxin SO3(ω-漏斗網(wǎng)蛛毒素SO3 ) | 0.5mg |
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08CON013-01000 | ω-conotoxin SO3(ω-漏斗網(wǎng)蛛毒素SO3 | 1mg | ||
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