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【產品簡介】
【詳細說明】
GaTx2
Selective blocker of ClC2 (CLCN2) chloride channels
氯離子通道蛋白2（CLCN2、CLC2）選擇性阻斷劑
GaTx2 (gating modifier of anion channels 2) was isolated from the venom of Leiurus quinquestriatus hebraeus. GaTx2 is the most potent peptide inhibitor of ClC-2 (CLCN2) chloride channel ever described. Kd value is close to 20 pM. GaTx2slows ClC-2 activation but without altering channel conductance. The effect is voltage-dependent. This inhibitory effect was highlighted on rabbit ClC-2 channels expressed in oocytes. It has no effect on ClC-0, ClC-1, ClC-3, ClC-4, CFTR, GABAC, Xenopus ClCa, Shaker B or Kv1.2 channels. Structurally, GaTx2 is composed of two β-strands and one α-helix. This peptide is also called Leiuropeptide II. Bears 89, 93 and 96% identity with OdK1, neurotoxin PO1 and leiuropeptide III, respectively.
GaTx2 技術資料
氨基酸序列：
H-Val-Ser-Cys3-Glu-Asp-Cys6-Pro-Asp-His-Cys10-Ser-Thr-Gln-Lys-Ala-Arg-Ala-Lys-Cys19-Asp-Asn-Asp-Lys-Cys24-Val-Cys26-Glu-Pro-Ile-OH
二硫鍵： Disulfide bonds between Cys3-Cys19, Cys6-Cys24, and Cys10-Cys26
長度 (aa)：29
分子式： C125H199N39O47S6
分子量： 3191.25 Da
外觀： White lyophilized solid
可溶性：water and saline buffer
CAS 號：not available
來源：Synthetic
純度： > 98 %
產品信息
10GTX002-00100 | GaTx2 | 0.1mg |
10GTX002-00500 | GaTx2 | 0.5mg |
10GTX002-01000 | GaTx2 | 1mg |