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CON020-µ-conotoxin GIIIB （u-芋螺毒素 GIIIB）
- 發(fā)布日期：
- 有效日期：
- 所 在 地：
- 產(chǎn) 地：
- 已獲點(diǎn)擊：
- 2025年4月24日
- 2025年10月24日
- 北京北京市
- 法國(guó)
- 214次
【產(chǎn)品簡(jiǎn)介】
【詳細(xì)說明】
µ-conotoxin GIIIB（µ-芋螺毒素 GIIIB）
Selective blocker of Nav1.4 channels(鈉離子通道Nav1.4選擇性阻斷劑)
µ-conotoxin GIIIB is a 22-mer peptide originally isolated from the venom of the piscivorous marine snail Conus geographus. µ-conotoxin GIIIB adopts a compact structure consisting of a distorted 310-helix and a small ß-hairpin. µ-conotoxin GIIIB is stabilized by three disulphide bridges and is highly enriched in lysine and arginine residues, forming potential sites of interaction with Na channels. An unusual feature is the presence of three hydroxyproline residues. µ-conotoxin GIIIB is a useful probe to discriminate between neuronal and muscle sodium channels as it exhibits at least a 1000-fold specificity for muscle versus nerve sodium channels. µ-Conotoxin GIIIB selectively blocks Nav1.4(µ1) voltage-dependent sodium channels, which are predominantly expressed in muscle, with an affinity close to 20 nM.µ-Conotoxin GIIIB appears to physically occlude the channel pore by binding on site I of the Na+ channel.
µ-conotoxin GIIIB 技術(shù)資料
氨基酸序列：
Arg-Asp-Cys3-Cys4-Thr-Hyp-Hyp-Arg-Lys-Cys10-Lys-Asp-Arg-Arg-Cys15-Lys-Hyp-Met-Lys-Cys20-Cys21-Ala-NH2
二硫鍵： Cys3-Cys15, Cys4-Cys20 and Cys10-Cys21
長(zhǎng)度 (aa)： 22
分子式： C101H175N39O30S7
分子量：2640.26 Da
外觀：White lyophilized solid
可溶性：water and saline buffer
CAS 號(hào)：not available
來(lái)源： Synthetic
純度：> 97 %
產(chǎn)品信息
CON020-50100 | µ-conotoxin GIIIB | 5x 0.01mg |
CON020-00100 | µ-conotoxin GIIIB | 0.1mg |
CON020-00500 | µ-conotoxin GIIIB | 0.5mg |
CON020-01000 | µ-conotoxin GIIIB | 1mg |