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            13129540117

            BioXcell熱銷(xiāo)產(chǎn)品--InVivoPlus anti-mouse CD8α

            時(shí)間:2023/5/17閱讀:514
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            BioXcell熱銷(xiāo)產(chǎn)品--InVivoPlus anti-mouse CD8α

             

            產(chǎn)品描述:

            BioXcell InVivoPlus anti-mouse CD8α克隆號(hào)YTS 169.4單克隆抗體能與小鼠CD8α反應(yīng)。CD8抗原是一種跨膜糖蛋白,作為T(mén)細(xì)胞受體的共受體。與TCR一樣,CD8與抗原呈遞細(xì)胞(APC)展示的I類MHC分子結(jié)合。CD8主要在細(xì)胞毒性T細(xì)胞表面表達(dá),但也可在胸腺細(xì)胞、自然殺傷細(xì)胞和一些樹(shù)突狀細(xì)胞亞群中發(fā)現(xiàn)。CD8最常見(jiàn)的存在形式是由一個(gè)CD8α和一個(gè)CD8β鏈組成的異二聚體,然而,它也可以是由兩個(gè)CD8α鏈組成的同二聚體。CD8α和CD8β鏈均與免疫球蛋白可變輕鏈具有顯著同源性。每個(gè)CD8鏈的分子量約為34 kDa。BioXcell InVivoPlus anti-mouse CD8α克隆號(hào)YTS 169.4抗體在體內(nèi)使用時(shí)顯示出depleting活性。


            BioXcell熱銷(xiāo)產(chǎn)品--InVivoPlus anti-mouse CD8α 

            產(chǎn)品詳情:


            產(chǎn)品名稱

            InVivoPlus anti-mouse CD8α

            產(chǎn)品貨號(hào)

            BP0117

            產(chǎn)品規(guī)格

            5/25/50/100mg

            反應(yīng)種屬

            Mouse

            克隆號(hào)

            YTS 169.4

            同種型

            Rat IgG2b, κ

            免疫原

            CBA mouse thymocytes

            實(shí)驗(yàn)應(yīng)用

            in vivo CD8+ T cell depletion
            Western blot

            產(chǎn)品形式

            PBS, pH 7.0,Contains no stabilizers or preservatives

            純度

            >95%, Determined by SDS-PAGE

            聚合

            <5%, Determined by SEC

            無(wú)菌處理

            0.2 µm filtration

            純化方式

            Protein G

            RRID

            AB_10950145

            分子量

            150 kDa

            小鼠病原檢測(cè)

            Ectromelia/Mousepox Virus: Negative

            Hantavirus: Negative

            K Virus: Negative

            Lactate Dehydrogenase-Elevating Virus: Negative

            Lymphocytic Choriomeningitis virus: Negative

            Mouse Adenovirus: Negative

            Mouse Cytomegalovirus: Negative

            Mouse Hepatitis Virus: Negative

            Mouse Minute Virus: Negative

            Mouse Norovirus: Negative

            Mouse Parvovirus: Negative

            Mouse Rotavirus: Negative

            Mycoplasma Pulmonis: Negative

            Pneumonia Virus of Mice: Negative

            Polyoma Virus: Negative

            Reovirus Screen: Negative

            Sendai Virus: Negative

            Theiler’s Murine Encephalomyelitis: Negative

            保存條件

            抗體原液保存在4°C,不能冷凍保存。

            推薦同型對(duì)照

            InVivoPlus rat IgG2b isotype control, anti-keyhole limpet hemocyanin(貨號(hào)BP0090)

            推薦抗體稀釋液

            InVivoPure pH 7.0 Dilution Buffer(貨號(hào)IP0070)



            為什么選擇InVivoPlus抗體?

            InVivoPlus級(jí)別的產(chǎn)品內(nèi)毒素含量更低,經(jīng)過(guò)多種實(shí)驗(yàn)驗(yàn)證,更適合用于體內(nèi)實(shí)驗(yàn)研究

            BioXcell熱銷(xiāo)產(chǎn)品--InVivoPlus anti-mouse CD8α


             該產(chǎn)品自上市已被多篇SCI文獻(xiàn)引用,品質(zhì)有保證,以下是部分已發(fā)表的文獻(xiàn)引用:


            應(yīng)用

            文章

            體內(nèi)CD8+T細(xì)胞耗竭

            (in vivo CD8+ T cell depletion)

            1. Vashist, N., et al. (2018). 'Influenza-Activated ILC1s Contribute to Antiviral Immunity Partially Influenced by Differential GITR Expression' Front Immunol 9: 505.

            2. Triplett, T. A., et al. (2018). 'Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme' Nat Biotechnol 36(8): 758-764.

            3. Carmi, Y., et al. (2015). 'Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity' Nature 521(7550): 99-104.

            4. Burrack, K. S., et al. (2015). 'Myeloid Cell Arg1 Inhibits Control of Arthritogenic Alphavirus Infection by Suppressing Antiviral T Cells' PLoS Pathog 11(10): e1005191.

            5. Wensveen, F. M., et al. (2015). 'NK cells link obesity-induced adipose stress to inflammation and insulin resistance' Nat Immunol 16(4): 376-385.

            6. Li, Z., et al. (2015). 'Pre-treatment of allogeneic bone marrow recipients with the CXCR4 antagonist AMD3100 transiently enhances hematopoietic chimerism without promoting donor-specific skin allograft tolerance' Transpl Immunol 33(2): 125-129.

             

             

            BioXcell熱銷(xiāo)產(chǎn)品--InVivoPlus anti-mouse CD8α

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