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            深圳欣博盛生物科技有限公司
                                                                        
            
										  中級會員 | 第5年									
            
                                    								
            

							
            
						
            
                        

					
            
										
            
						
            
                            							
            
								
            
								
            
									
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            BioXcell熱銷產(chǎn)品InVivoMab anti-mouse CD28/小鼠CD28單克隆抗體
            
						
            
							時間：2023/7/5閱讀：534
							
            
							
				
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            BioXcell熱銷產(chǎn)品InVivoMab anti-mouse CD28/小鼠CD28單克隆抗體

            產(chǎn)品描述：

            The 37.51 monoclonal antibody reacts with mouse CD28, a 45 kDa costimulatory receptor and a member of the Ig superfamily. CD28 is expressed by thymocytes, most peripheral T cells, and NK cells. CD28 is a receptor for CD80 (B7-1) and CD86 (B7-2). Signaling through CD28 augments IL-2 and IL-2 receptor expression as well as cytotoxicity of CD3-activated T cells. The 37.51 antibody has been shown to stimulate the proliferation and cytokine production by activated T and NK cells and provide a costimulatory signal for CTL induction.

            BioXcell InVivoMab anti-mouse CD28 37.51單克隆抗體與小鼠CD28反應(yīng)，CD28是一種45kDa的共刺激受體，也是Ig超家族的一員。CD28由胸腺細(xì)胞，大多數(shù)外周T細(xì)胞和NK細(xì)胞表達(dá)。CD28是CD80（B7-1）和CD86（B7-2）的受體。通過CD28的信號傳導(dǎo)增強(qiáng)了IL-2和IL-2受體的表達(dá)以及CD3活化的T細(xì)胞的細(xì)胞毒性。37.51抗體已被證明能刺激活化的T細(xì)胞和NK細(xì)胞的增殖和細(xì)胞因子的產(chǎn)生，并為CTL誘導(dǎo)提供共刺激信號。
            BioXcell熱銷產(chǎn)品--InVivoMab anti-mouse CD28 

            產(chǎn)品詳情：
            產(chǎn)品名稱
            InVivoMAb anti-mouse CD28
            產(chǎn)品貨號
            BE0015-1
            產(chǎn)品規(guī)格
            1/5/25/50/100mg
            反應(yīng)種屬
            Mouse
            克隆號
            37.51
            同種型
            Syrian Hamster IgG2
            免疫原
            C57BL/6 mouse T cell lymphoma EL-4 cells
            實驗應(yīng)用
            in vitro T cell stimulation/activation
            in vivo CD28 blockade
            產(chǎn)品形式
            PBS, pH 6.0 0.01% Tween,Contains no stabilizers or preservatives
            純度
            >95%, Determined by SDS-PAGE
            無菌處理
            0.2 µm filtration
            純化方式
            Protein G
            RRID
            AB_1107624
            分子量
            150 kDa
            保存條件
            抗體原液保存在4°C，不能冷凍保存。
            推薦同型對照
            InVivoMAb polyclonal Syrian hamster IgG（貨號BE0087）
            推薦抗體稀釋液
            InVivoPure pH 6.0T Dilution Buffer（貨號IPT060）
             
             該產(chǎn)品自上市已被多篇SCI文獻(xiàn)引用，品質(zhì)有保證，以下是部分已發(fā)表的文獻(xiàn)引用：

            應(yīng)用
            文章
            體外T細(xì)胞刺激/激活
            (in vitro T cell stimulation/activation)
            1. Lacher, S. M., et al. (2018). 'NF-kappaB inducing kinase (NIK) is an essential post-transcriptional regulator of T-cell activation affecting F-actin dynamics and TCR signaling' J Autoimmun 94: 110-121.
            2. Wendland, K., et al. (2018). 'Retinoic Acid Signaling in Thymic Epithelial Cells Regulates Thymopoiesis' J Immunol 201(2): 524-532.
            3. Ron-Harel, N., et al. (2016). 'Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation' Cell Metab 24(1): 104-117.
            4. Gu, A. D., et al. (2015). 'A critical role for transcription factor Smad4 in T cell function that is independent of transforming growth factor beta receptor signaling' Immunity 42(1): 68-79.
            5. Choi, Y. S., et al. (2015). 'LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6' Nat Immunol 16(9): 980-990.  
            體內(nèi)CD28阻斷
            (in vivo CD28 blockade)
            1. Rouhani, S. J., et al. (2015). 'Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction' Nat Commun 6: 6771.
            2. Eberlein, J., et al. (2012). 'Multiple layers of CD80/86-dependent costimulatory activity regulate primary, memory, and secondary lymphocytic choriomeningitis virus-specific T cell immunity' J Virol 86(4): 1955-1970.
             
             
            BioXcell熱銷產(chǎn)品--InVivoMab anti-mouse CD28

            更多產(chǎn)品詳情請聯(lián)系 BioXcell 中國授權(quán)代理——欣博盛生物
            
							
							
							
						
            
					
            
				
            
			
            
		
            
		
		
		
		 



  
    
    				
			

		
    
    
    
    
    
    
    
    
    
    

    

     
     
     
	 




	 
	
	
	

            
	
            
		
            
			
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