The 14G2a monoclonal antibody reacts with human ganglioside GD2 a sialic-acid bearing glycolipid that is involved in mediating cell attachment to the extracellular matrix. Ganglioside GD2 is expressed on tumors of neuroectodermal origin including human neuroblastoma and melanoma. The tumor specific expression of GD2 makes it a suitable target for immunotherapy with monoclonal antibodies or with artificial T cell receptors. Clone 14G2a is an isotype switch variant selected from the parental IgG3-producing hybridoma 14.18 and has identical reactivity as the parental antibody.

產(chǎn)品名稱(chēng):InVivoMAb anti-human Ganglioside GD2

反應(yīng)種屬:human

宿主來(lái)源:Mouse

實(shí)驗(yàn)應(yīng)用:in vitro induction of apoptosis in GD2+ cells, in vivo inhibition of GD2+ tumor cell growth

同種型:IgG2a, κ

免疫原:Neuroblastoma cell line LAN-1

克隆性:Monoclonal

克隆號(hào):14G2a

產(chǎn)品濃度:Lot specific,typically between 4-11 mg/ml

保存溫度:Undiluted at 4°C in the dark

運(yùn)輸溫度:Ship with adequate amount of blue ice to ensure the product remains at 4°C for the duration of transit

預(yù)期分子量:150 kDa

產(chǎn)品形式:液體

有效期:One year from the date of receipt if stored as recommended

產(chǎn)地:美國(guó)

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