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            深圳欣博盛生物科技有限公司
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            R848 (Resiquimod)

            參   考   價(jià): 1950

            訂  貨  量: ≥1  瓶

            具體成交價(jià)以合同協(xié)議為準(zhǔn)

            產(chǎn)品型號(hào)

            品       牌Invivogen

            廠商性質(zhì)代理商

            所  在  地深圳市

            更新時(shí)間:2022-01-28 15:34:55瀏覽次數(shù):988次

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            供貨周期 現(xiàn)貨 規(guī)格 500 μg
            貨號(hào) tlrl-r848 應(yīng)用領(lǐng)域 生物產(chǎn)業(yè)
            主要用途 科研
            TLR7/8 Agonist - Imidazoquinoline compound
            R848 (Resiquimod) is an imidazoquinoline compound with potent anti-viral activity. This low molecular weight synthetic molecule activates immune cells via ……

            TLR7/8 Agonist - Imidazoquinoline compound

            R848 (Resiquimod) is an imidazoquinoline compound with potent anti-viral activity. This low molecular weight synthetic molecule activates immune cells via the TLR7/TLR8 MyD88-dependent signaling pathway [1, 2].

            Recently, R848 was shown to trigger NF-κB activation in cells expressing murine TLR8 when combined with poly(dT) [3].

            Unlike other commercially available R848 preparations, InvivoGen's R848 is water soluble, validated for TLR7/8 potency and tested to ensure the absence of TLR2 or TLR4 contamination.

             

            References:

            1. Hemmi H. et al., 2002. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol, 3(2):196-200.
            2. Jurk M. et al. 2002. Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R848. Nat Immunol, 3(6):499.
            3. Gorden KKB. et al., 2006. Cutting Edge: Activation of Murine TLR8 by a Combination of Imidazoquinoline Immune Response Modifiers and PolyT Oligodeoxynucleotides J. Immunol., 177: 6584 - 6587.


            Specifications

            Specificity: TLR7 and TLR8

            Working Concentration: 10 ng - 10 μg/ml

            CAS number: 144875-48-9 (free base)

            Solubility: 1 mg/ml in water

            Formula: C17H22N4O2 • HCl

            Molecular weight: 350.8 g/mol


            Contents

            R848 (Resiquimod) is provided lyophilized and is available in two quantities:

            • tlrl-r848: 500 µg + 1.5 ml of sterile endotoxin-free water.

            • tlrl-r848-5: 5 mg + 10 ml of sterile endotoxin-free water.

             R848 is shipped at room temperature.

             Upon receipt it should be stored at 4°C or -20°C.


            如需購(gòu)買(mǎi)或咨詢(xún)?cè)摦a(chǎn)品技術(shù)問(wèn)題,請(qǐng)聯(lián)系Invivogen一級(jí)代理商-欣博盛生物

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