狠狠色丁香久久综合婷婷亚洲成人福利在线-欧美日韩在线观看免费-国产99久久久久久免费看-国产欧美在线一区二区三区-欧美精品一区二区三区免费观看-国内精品99亚洲免费高清

Cyclopamine(11-deoxojervine) CAS:4449-51-8   環(huán)巴胺(環(huán)杷明)Cyclopamine(11-deoxojervine)

Appearance:White crystalline solid 
Assay(HPLC): >99%

Product Name: Cyclopamine(11-Deoxyjervine)
Botanical Source: Veratrum californicim (plant extract) 
CAS No.: 4449-51-8
Synonyms:11-Deoxojervine; (3b,23b)-17,23-Epoxy-11-deoxoveratraman-3-ol 
Chemical Name: (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,
11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol
Molecular Formula:C₂₇H₄₁NO₂
Molecular Weight  411.62
Appearance: White to off-white powder 
Solubility: Soluble in * ethanol (20mg/ml), DMSO (4mg/ml), dimethyl formamide (10mg/ml), methanol (7mg/ml). Insoluble in water.
Purity: >99% (HPLC)

Description:
Cyclopamine is a natural steroidal jerveratrum alkaloide. Cyclopamine is named after its ability to cause cyclopia(holoprosencephaly) in unborn sheep.
Cyclopamine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling. It specifically inhibits the hedgehog (Hh) pathway by interaction with the Hh signaling protein smoothened. Cyclopamine blocks the oncogenic effects of mutations of Ptch in fibroblasts and inhibits the growth of cells lacking Ptch function. It arrested cell cycle at G0/G1 and induced apoptosis in several small-cell lung cancer cell lines at 5 µM. Cyclopamine also induces expression of the transcription factor pdx-1, which stimulates insulin secretion in differentiation protocols for mouse embryonic stem cells.