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Description

Complex of NLRP3 and NEK7 proteins. The two proteins were co-expressed and affinity purified.

Recombinant human NLRP3 (NLR family pyrin domain containing 3), encompassing amino acids 134-1036 (end). The construct does not contain the pyrin domain (also called DAPIN domain or PYD), which is involved in PYCARD binding. It contains an N-terminal FLAG-tag followed by an Avi-Tag™.

Recombinant human NEK7 (NIMA related kinase 7), encompassing amino acids 2-302 (end). This construct contains an N-terminal His-tag (7xHis).

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Synonyms

NACHT, LRR and PYD domains-containing protein 3, AII, AVP, FCU, MWS, FCAS, KEFH, CIAS1, FCAS1, NALP3, C1orf7, Caterpillar protein 1.1, CLR1.1, DFNA34, PYPAF1, AGTAVPRL, Cryopyrin, NIMA related kinase 7, Never in mitosis A-related kinase 7

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