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Tiron

CAS No. : 149-45-1

產(chǎn)品活性：Tiron is a non-toxic chelator of a variety of metals. Tiron is cell permeable analog of vitamin E and function as hydroxyl radical and superoxide scavenger. Tiron is an orally active antioxidant. Tiron can be used to alleviate acute metal overload in animals.

研究領(lǐng)域：Others  |  Apoptosis

作用靶點：Biochemical Assay Reagents  |  Apoptosis

In Vitro: Tiron (10 mM) protects Chinese hamster V79 cells against H₂O₂-induced cytotoxicity.
Tiron (0-20 mM) protects supercoiled DNA from metal-mediated superoxide-dependent strand breaks.
Tiron (50 nM-200 nM, 48 h) inhibits HG-induced neonatal rat cardiomyocytes apoptosis.
Tiron (50 nM-200 nM, 48 h) reduces intracellular osteopontin in neonatal rat cardiomyocytes.
Tiron (0.2 mM, 2 h) inhibits UVB-induced up-regulation of MMP-1 and MMP-3 in HDFs.
Tiron (0.7 mM, 48 h) increases the percentage of PT4 cells in both the S and G2/M phases.

In Vivo: Tiron (200 mg/kg, oral gavage) ameliorates oxidative stress and inflammation in a murine model of airway remodeling.
Tiron (300 mg/kg, i.p., daily for two weeks) alleviated apoptosis of the left ventricular cardiomyocytes in STZ-induced diabetic mice.

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