目錄:MedChemExpress LLC>>信號通路>> AGI-24512 | MedChemExpress
| CAS | 2201066-53-5 | 純度 | 99.48% |
|---|---|---|---|
| 分子量 | 400.47 | 分子式 | C??H??N?O? |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL |
| 貨號 | HY-112130 | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥/生物制藥 |
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CAS No. : 2201066-53-5
MCE 國際站：AGI-24512
產(chǎn)品活性：AGI-24512 是一種蛋氨酸腺苷轉(zhuǎn)移酶 2α (MAT2A) 抑制劑，IC50 為 8 nM。AGI-24512 觸發(fā) DNA 損傷反應(yīng)。AGI-24512 可阻斷 MTAP 缺失的癌細胞體外增殖。AGI-24512可用于抗癌研究。
研究領(lǐng)域：Epigenetics | Metabolic Enzyme/Protease
作用靶點：Methionine Adenosyltransferase (MAT)
In Vitro: AGI-24512 (0-1 μM; 96 hours) blocks proliferation of MTAP (methylthioadenosine phosphorylase)-deleted HCT116 cancer cells with an IC50 of 100 nM.
?AGI-24512 significantly increases in γH2AX-positive cells in MTAP-/- HCT116 cells.
?AGI-24512 inhibits PRMT5-mediated SDMA marks with an IC50 of 95 nM in MTAP-/- cells.
?AGI-24512 leads to a dose-dependent decrease in SAM (S-adenosylmethionine) levels in the HCT116 MTAP-null cell, with an IC50 of 100 nM.
In Vivo: AGI-24512 shows poor oral absorption and a short half-life in rats.
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