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The STAT3 Luciferase Reporter HEK293 Cell Line is a HEK293 cell lines expressing firefly luciferase driven by STAT3 response elements located upstream of a minimal TATA promoter. After activation by cytokines or growth factors, endogenous STAT3 binds to the response elements, inducing transcription of the luciferase reporter.
This cell line has been validated to respond to human interleukin-6 (IL-6) and human IL-27. Functional validation experiments showed that IL-6-induced luciferase activity was decreased by the JAK inhibitor CP 690,550 and by an anti-IL-6 Receptor neutralizing antibody.
Figure 1: Illustration of the mechanism behind reporter expression in the STAT3 Luciferase Reporter HEK293 Cell Line.
Created with BioRender.com
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Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.
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