目錄:亞科因(武漢)生物技術(shù)有限公司>>細胞因子及蛋白>>細胞因子>> Mouse RSPO1/R-spondin-1 Protein重組小鼠RSPO1/R-spondin-1 蛋白(RSPO1/R-spondin-1)
產(chǎn)品英文名稱 | Mouse RSPO1/R-spondin-1 Protein |
產(chǎn)品中文名稱 | 重組小鼠RSPO1/R-spondin-1 蛋白(RSPO1/R-spondin-1) |
別名 | RSPO1, Roof plate-specific spondin-1 |
標簽 | 無標簽 |
表達宿主 | 大腸桿菌 |
種屬 | 小鼠 |
序列 | 氨基酸序列來源于:小鼠源RSPO1 (Q9Z132) (Ser21-Gln265) 表達的蛋白片段。 |
活性 | Testing in Progress |
蛋白長度 | 重組小鼠RSPO1由245個氨基酸組成,預測分子量為27.2KD。 |
純度 | > 98 % ,使用SDS-PAGE檢測 |
特點&優(yōu)勢 | 通過LAL法測定,每微克蛋白里內(nèi)毒素含量<0.1>0.1> |
產(chǎn)品形式 | 凍干粉,凍干緩沖液為無菌的20 mM Tris,50 mM NaCl,pH 8.0。 |
基因ID | 11450 |
蛋白序列鏈接 | Rspo1 - R-spondin-1 - Mus musculus (Mouse) | UniProtKB | UniProt |
使用中注意事項 | 開蓋使用前,請先離心。本產(chǎn)品為凍干粉,推薦用該產(chǎn)品配套的Reconstitution Buffer進行復溶,且濃度不低于109 µg/mL??蛻艨筛鶕?jù)后續(xù)的實驗需求,進行進一步的稀釋。 |
保存建議 | 本產(chǎn)品為凍干粉形式,建議:將凍干粉產(chǎn)品保存于-20℃以下的干燥環(huán)境中。本產(chǎn)品溶解之后,可在4℃保存2-7天,長期使用請置于-20℃以下。為長期保存,推薦添加載體蛋白(0.1% HSA或者BSA),并酌情分裝保存,避免反復凍融。 |
運輸條件 | 冰袋運輸(藍冰) |
警告 | 本文列出的產(chǎn)品僅供研究使用,不適用于人類或臨床診斷。我們產(chǎn)品所推薦應用,不是建議使用我們的產(chǎn)品去違反任何或許可證。對于使用本產(chǎn)品可能發(fā)生的侵權(quán)或其他違規(guī)行為,我們不承擔任何責任。 |
背景 | RSPO1 is a secreted protein,containing 2 FU(furin-like) repeats and 1 TSP type-1 domain and belonging to the R-spondin family. RSPO1 is required for the early development of gonads, regardless of sex. It has been found in mice only eleven days after fertilization. To induce cell proliferation, it acts synergistically with WNT4. They help stabilize β catenin, which activates downstream targets. RSPO1 is necessary in female sex development. It augments the WNT/β catenin pathway to oppose male sex development. In critical gonadal stages, between six and nine weeks after fertilization, the ovaries upregulate it while the testes downregulate it. RSPO1 can potentially aid in the treatment of mucositis, which is characterized by inflammation of the oral cavity. This unfortunate condition often accompanies chemotherapy and radiation in cancer patients with head and neck tumors. |
Fig.Mouse RSPO1 Protein