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商品信息

產(chǎn)品英文名稱	Human Noggin Protein, His tag
產(chǎn)品中文名稱	重組人Noggin蛋白，His-標簽（Noggin）
別名	Nog

商品屬性

表達宿主	大腸桿菌
種屬	人
序列	氨基酸序列來源于：人源Noggin (Q13253) (Gln28-Cys232) 表達的蛋白片段。
活性	Testing in Progress
蛋白長度	重組人Noggin由206個氨基酸組成，預測分子量為23.2 KD。
純度	> 98 % ，使用SDS-PAGE檢測
特點&優(yōu)勢	通過LAL法測定，每微克蛋白里內(nèi)毒素含量<0.1>
產(chǎn)品形式	凍干粉，凍干緩沖液為無菌的20 mM Tris，50 mM NaCl，pH 8.0。
基因ID	25317
蛋白序列鏈接	NOG - Noggin - Homo sapiens (Human) | UniProtKB | UniProt
使用中注意事項	開蓋使用前，請先離心。本產(chǎn)品為凍干粉，推薦用該產(chǎn)品配套的Reconstitution Buffer進行復溶，且濃度不低于102 µg/mL?？蛻艨筛鶕?jù)后續(xù)的實驗需求，進行進一步的稀釋。
保存建議	本產(chǎn)品為凍干粉形式，建議：將凍干粉產(chǎn)品保存于-20℃以下的干燥環(huán)境中。本產(chǎn)品溶解之后，可在4℃保存2-7天，長期使用請置于-20℃以下。為長期保存，推薦添加載體蛋白（0.1% HSA或者BSA），并酌情分裝保存，避免反復凍融。
運輸條件	冰袋運輸（藍冰）
警告	本文列出的產(chǎn)品僅供研究使用，不適用于人類或臨床診斷。我們產(chǎn)品所推薦應用，不是建議使用我們的產(chǎn)品去違反任何或許可證。對于使用本產(chǎn)品可能發(fā)生的侵權(quán)或其他違規(guī)行為，我們不承擔任何責任。

附加信息

背景

The secreted polypeptide Noggin, encoded by the Noggin gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, Noggin may have a principal role in creating morphogenic gradients. Noggin appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of Noggin suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as Noggin. All Noggin mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of human Noggin is highly homologous to that of Xenopus, rat and mouse.

圖片及說明