Jingzhaotoxin III（JZTx-III，敬釗纓毛蛛毒素-III）

Selective blocker of Na_v1.5 channel(鈉離子通道Na_v1.5選擇性阻斷劑)

Jingzhaotoxin-III (ß-TRTX-Cj1α) has been isolated initially from the Chinese Tarantula spider Chilobrachys Jingzhaovenom. Jingzhaotoxin-III selectively inhibits the activation of the voltage-dependent sodium channel Na_v1.5 with an IC₅₀value close to 350 nM. It is inactive on Na_v1.2, Na_v1.4, Na_v1.6 and Na_v1.7 and should therefore be considered as an interesting research tool to discriminate between sodium channel subtypes. Jingzhaotoxin-III binds onto receptor site 4 presumably located on DIIS3-S4 linker of Na_v1.5 and supposedly blocks Na_v1.5 through a different mechanism than ProTx-II and  Huwentoxin IV. ß-TRTX-Cj1α is composed of 36 amino acid residues including 6 cysteines cross-linked according to a C1-C4, C2-C5 and C3-C6 pattern. Jingzhaotoxin-III also inhibits K_v2.1 channel with an IC₅₀ of around 700 nM. 

Jingzhaotoxin-III（敬釗纓毛蛛毒素-III）技術(shù)資料

氨基酸序列：Asp-Gly-Glu-Cys⁴-Gly-Gly-Phe-Trp-Trp-Lys-Cys¹¹-Gly-Arg-Gly-Lys-Pro-Pro-Cys¹⁸-Cys¹⁹-Lys-Gly-Tyr-Ala-Cys²⁴-Ser-Lys-Thr-Trp-Gly-Trp-Cys³¹-Ala-Val-Glu-Ala-Pro-OH 

二硫鍵： Cys⁴-Cys¹⁹, Cys¹¹-Cys²⁴, and Cys¹⁸-Cys³¹ 

長度（aa）：36 

分子式：C₁₇₄H₂₄₁N₄₇O₄₆S₆ 

分子量： 3919.53 Da 

外觀：White lyophilized solid 

可溶性：aqueous buffer 

CAS號：not available 

來源：Synthetic 

純度：> 98%

產(chǎn)品信息