Margatoxin（MgTx，瑪格斑蝎毒素） 

K_v1.3 selective blocker(鉀離子通道Kv1.3選擇性阻斷劑)

Margatoxin (MgTx) is a component of the venom of Scorpio Centruroides margaritatus. Margatoxin preferentially inhibits voltage-dependent potassium channels K_v1.3 with an IC₅₀ value around 50 pM (20 fold more potent than Charybdotoxin) and irreversibly inhibits the proliferation response   of human T-cells at 20 µM concentration. 

Margatoxin is known to be less potent on K_v1.3  expressed in Xenopus Oocytes (IC₅₀ around 1 nM). Margatoxin was also described to be a potent inhibitor of human vascular smooth muscle cell migration with an IC₅₀ of 85 pM.

Margatoxin 技術(shù)資料

氨基酸序列：Thr-Ile-Ile-Asn-Val-Lys-Cys⁷-Thr-Ser-Pro-Lys-Gln-Cys¹³-Leu-Pro-Pro-Cys¹⁷-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys²⁹-Met-Asn-Gly-Lys-Cys³⁴-Lys-Cys³⁶-Tyr-Pro-His-OH 

二硫鍵：Disulfide bonds between Cys⁷-Cys²⁹, Cys¹³-Cys³⁴ and Cys¹⁷-Cys³⁶)

長度 (aa)： 39 

分子式：C₁₇₈H₂₈₆N₅₂O₅₀S₇ 

分子量： 4179.03 Da 

外觀： White lyophilized solid 

可溶性： water and saline buffer 

CAS 號(hào)： [145808-47-5] 

來源： Synthetic  

純度： > 97 %

產(chǎn)品信息