Cyclin D1(周期素D1)兔單克隆抗體

廣州健侖生物科技有限公司

CyclinD1(PRAD-1或bcl-1)是一個重要的細胞周期調(diào)節(jié)因子，功能與細胞周期素依賴激酶4或細胞周期素依賴激酶6 磷酸化Rb蛋白有關(guān)。它是一個有爭議的原癌基因,在許多人類腫瘤包括套細胞淋巴瘤中表達。

簡單來講，細胞周期可以分為四個階段：G0/G1、S、G2及M。G1和G2期是細胞生長期；S期是細胞將細胞核內(nèi)的染色體復(fù)制的時期；M期是細胞進行有絲分裂(mitosis)或減數(shù)分裂(meiosis)的時期。
在各個時期各有不同的周期素所調(diào)控著，不同的周期素在細胞周期的不同階段發(fā)生作用。細胞周期的主要周期素有：cyclin A, cyclin B, cyclin D及cyclin E。在G1期→S期調(diào)控蛋白為細胞周期蛋白D1(cyclin D1)以及細胞周期蛋白E(cyclin E)，s期→G2期調(diào)控蛋白為細胞周期蛋白A(cyclin A)，G2期→M期調(diào)控蛋白為細胞周期蛋白B(cyclin B)。
每一個周期素都有一個共同位叫cyclin box。cyclin box的功能是激活一種叫周期素激酶(cyclin-dependent kinase; CDK)。
不同的周期素激酶在細胞周期的不同階段發(fā)生作用。例如：cyclin D激活CDK4或CDK6掌控G1期的細胞生長；cyclin A及cyclin E激活CDK2調(diào)控染色體復(fù)制；cyclin A及cyclin B激活CDK1調(diào)控有絲分裂和減數(shù)分裂。有趣的是，有些周期素雖然擁有cyclin box但它們沒有可激活的CDK：例如cyclin F, cyclin I以及cyclin G。而且cyclin I并沒有細胞周期的調(diào)控功能，它主要作用在神經(jīng)細胞上。

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Cyclin D1(周期素D1)兔單克隆抗體

【產(chǎn)品介紹】

細胞定位：細胞核

克隆號：SP4

同型：IgG

適用組織：石蠟/冰凍

陽性對照：套細胞淋巴瘤

抗原修復(fù)：熱修復(fù)（EDTA）

抗體孵育時間：30-60min

Cyclin D1(周期素D1)兔單克隆抗體

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【公司名稱】 廣州健侖生物科技有限公司
【市場部】     歐

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室

CyclinD1 (PRAD-1 or bcl-1) is an important cell cycle regulator that functions in conjunction with cyclin-dependent kinase 4 or cyclin-dependent kinase 6 phosphorylation of Rb protein. It is a controversial oncogene that is expressed in many human tumors, including mantle cell lymphoma.

In simple terms, the cell cycle can be divided into four stages: G0 / G1, S, G2 and M. The G1 and G2 phases are the cell growth phase; the S phase is the period in which the cells replicate the chromosomes in the nucleus; and the M phase is the period in which the cells undergo mitosis or meiosis.
In different periods of different cyclins regulation, different cyclins in the different stages of the cell cycle play a role. The main cell cycle cycle are: cyclin A, cyclin B, cyclin D and cyclin E. In the G1 phase → S phase, the regulatory proteins are cyclin D1 and cyclin E, and the s-phase → G2-phase regulatory proteins are cyclin A, G2 → M phase regulation The protein is cyclin B.
Every cyclotron has a common denominator called a cyclin box. The function of the cyclin box is to activate a cell cycle called cyclin-dependent kinase (CDK).
Different cyclin kinases act at different stages of the cell cycle. For example, cyclin D activates CDK4 or CDK6 to control G1 cell growth; cyclin A and cyclin E activate CDK2 to regulate chromosome replication; and cyclin A and cyclin B activate CDK1 to regulate mitosis and meiosis. Interestingly, although some cyclin have a cyclin box, they do not have an activatable CDK: cyclin F, cyclin I, and cyclin G, for example. And cyclin I does not have the cell cycle regulatory function, it mainly acts on nerve cells.