Melanoma Associated Antigen(MAA)

廣州健侖生物科技有限公司

黑色素瘤相關(guān)性抗原KBA.62其敏感性與S-100p相似，但對促纖維樣,紡錘樣細(xì)胞黑色素瘤和前哨微量淋巴結(jié)轉(zhuǎn)移有較高特異性。

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Melanoma Associated Antigen(MAA)

【產(chǎn)品介紹】

細(xì)胞定位：細(xì)胞膜

克隆號:KBA.62

同型：IgG

適用組織：石蠟/冰凍

陽性對照：黑色素瘤

抗原修復(fù)：熱修復(fù)（EDTA）

抗體孵育時(shí)間：30-60min

Melanoma Associated Antigen(MAA)

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【公司名稱】 廣州健侖生物科技有限公司
【市場部】     歐

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室

研究人員測量了抗原抗體癌細(xì)胞核和胞液內(nèi)的機(jī)械性能，然后測量了不同基質(zhì)上細(xì)胞的表面牽引力和運(yùn)動(dòng)性。他們發(fā)現(xiàn)，細(xì)胞變得更加柔軟，這可以幫助它們在體內(nèi)蔓延。
Dawson實(shí)驗(yàn)室與佐治亞理工學(xué)院生物學(xué)院的John McDonald教授實(shí)驗(yàn)室合作，利用微陣列分析，來檢測所觀察到的生物物理變化有關(guān)的基因變化。研究人員發(fā)現(xiàn)，無論細(xì)胞生長的基質(zhì)怎樣，過度表達(dá)SNAIL的細(xì)胞看起來、以及表現(xiàn)得都很像侵襲性的癌細(xì)胞。
Dawson說：“我們發(fā)現(xiàn)，當(dāng)細(xì)胞表達(dá)SNAIL時(shí)，它們的生物物理特性類似于激活的轉(zhuǎn)移性癌細(xì)胞。”
雖然SNAIL可觸發(fā)一種轉(zhuǎn)換，幫助細(xì)胞從原發(fā)腫瘤部位移動(dòng)到轉(zhuǎn)移部位，但是，一旦細(xì)胞到達(dá)轉(zhuǎn)移部位，腫瘤就開始生長，SNAIL就不再有助于癌癥進(jìn)展。雖然變得柔軟可以幫助細(xì)胞擴(kuò)散至次級部位，但是它們不再足夠結(jié)實(shí)，因此就不能形成繼發(fā)性腫瘤。Dawson說：“這些細(xì)胞需要轉(zhuǎn)移回上皮狀態(tài)，這樣它們就能承受固體應(yīng)力。”
研究人員希望，他們將微陣列分析，與發(fā)生轉(zhuǎn)移的抗原抗體癌細(xì)胞物理變化的表征*地結(jié)合，可以幫助尋找方法阻止或減緩癌癥的擴(kuò)散。

Researchers measured the mechanical properties in the nuclei and cytosol of antigen-antibody cancer cells and then measured the surface traction and motility of cells on different stroma. They found that the cells became softer, which helped them spread in the body.
Dawson Laboratories, in collaboration with Professor John McDonald's Laboratory at the Georgia Tech Institute of Biology, uses microarray analysis to detect observed changes in biophysical changes. The researchers found that regardless of the cell growth matrix, cells that over-express SNAIL looked and behaved much like aggressive cancer cells.
Dawson said: "We found that when cells express SNAIL, their biophysical properties are similar to activated metastatic cancer cells."
Although SNAIL triggers a switch that helps cells move from the primary tumor site to the metastatic site, tumors start to grow once the cells reach the metastatic site and SNAIL no longer contributes to cancer progression. Although becoming soft helps cells to spread to the secondary site, they are no longer strong enough to form secondary tumors. Dawson said: "These cells need to be transferred back to the epithelium, so they can withstand solid stress."
The researchers hope that they will uniquely combine microarray analysis with characterization of the physical changes in metastatic antigen-presenting cancer cells, helping to find ways to stop or slow the spread of cancer.