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SR-X超靈敏單分子蛋白檢測(cè)系統(tǒng)是Ouanterix公司最新推出的基于Simoa@技術(shù)的桌面型分析儀。致力于幫助研究人員在一個(gè)緊湊、高效的系統(tǒng)中獲得超高靈敏度的蛋白質(zhì)和核酸檢測(cè)能力。SR-X可同時(shí)在血液中直接檢測(cè)高達(dá)4種生物標(biāo)志物,樣本體積小,幫助節(jié)約珍貴的樣本和降低實(shí)驗(yàn)成本，同時(shí)數(shù)據(jù)具備重復(fù)性和準(zhǔn)確性。研究人員可使用超過(guò)80種Simoa@商品化試劑盒檢測(cè)重要的生物標(biāo)志物,適應(yīng)各種樣本類型,靈敏度比傳統(tǒng)ELISA高出1000倍，可檢測(cè)正常和疾病情況下的生物標(biāo)志物水平。此外,SR-X還為研究人員提供了更為靈活地客制化實(shí)驗(yàn)(Homebrew方案,用戶可自行開發(fā)新的靶點(diǎn),從血液中檢測(cè)蛋白質(zhì)(Protein)、核酸(Nucleic Acid)或者miRNA等標(biāo)志物,不再需要復(fù)雜的提取和易出錯(cuò)的擴(kuò)增步驟。整體檢測(cè)靈敏度與全自動(dòng)的HD-XTM分析儀保持一致,操作靈活,適合廣大科研工作者的實(shí)驗(yàn)需求。

國(guó)內(nèi)外使用Simoa®平臺(tái)發(fā)表重要文獻(xiàn)

神經(jīng)領(lǐng)域

1.Rissin D M ,e al. Single-molecule enzyme-linked immunosorbent assay delects serum proteins at sublemtomolar concentrationsNature Biotechnology, 28(6):595-599.

2.Wendeln AC, et al. innate immune memory in the brain shapes neurological disease hallmarks Nature. 2018 Apr:556(770):332-338

3.Preische 0. et al. Serum neurohlament dynamics predicis neurodereneration and cinical proeresson in presymptomatic Alzheimer.disease. Nat Med. 2019 Feb,25(2):277-283.

4.Rotstein D, et al. Reaching an evidence-based pro gnosis or pesonalized treatment of multiple sclerosis. Nat Rev Neurol. 201gMay15(5:287-300.

5.Arboleda-Velasquez]F, et al. esistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a casereport. Mat Med. 2019 Nov:25(1D:1680-1683.

6. Gate D, et al. Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease. Nature. 2020lan:57707790399-404.

7.Thjssen EH, et al. Diagnostic value of plasma phosphorylated tau81 in Alzheimer's disease and frontotempora! lobar degenerationMat Med. 2020 Mar:26(3):387-397.

8. Gao F,et al. A combination model of AD biomarkers revealed by machine leaming precisely predicts Alzheimer's dementia: ChinaAging and Neurodegenerative lnitiative (CANDD study. Alzheimers Dement 2022 un 6.9.

9.Jiang, Y, et al. An ILIRL1 geneic variant lowers soluble 5T2 levels and the risk efects of APOE-E4 in female patients with Alzheimer'sdisease Nat Aging 2, 616-634(2022).

10.Wang L, et al. Association of erebrospinal Fluid Neuroflament Heawy Protein Levels With Clinical Pro gression in Patients WithParkinson Disease. ]AMA Netw Open. 2022 ]ul 1:5(7):e2223821.

感染領(lǐng)域

Laing AG,et al. A dynamic COMD-19 immune signature includes associations with poor prognosis. Nat Med. 2020 0ct26(10):1623-1635

腫瘤領(lǐng)域

Shi Y, et al Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. 2019May:569(7754):31-135.

生殖領(lǐng)城

Chen P, et al. Granulocyte-Macrophage Colony Stimulating Faclor in Single Blastocyst Conditioned Medjum as a Biomarker for Predict-ing lmplantation Outcome of Embryo. Front lmmunol. 2021Jun 3012:679839.

眼科

GaoF,Hong X, Ding F, Huang 5, Ljan W, Wang H,Zheng W, Ni], Chen M, Lju Q.High Level of nfammatory ytokines in the Tears: ABrid ge of Patients with Concomitant Exo tropia and Dry Eye. Oxid Med Cell Longev. 2021 0ct 7,2021:5662550

自身免投病

Casey KA, et al. Modulation of Cardiometabolic Disease Markers by Type interteron lnhibition in 5ystemic Lupus ErythematosusArthritis Rheumatol 2021 Mar733)459-471.

心血管

Wihersaaril, et al. Neuro filament light as an outcome prediclor after cardiac arrest a post hoc analysis of the COMACARE trial. intensiveCare Med.2020.