狠狠色丁香久久综合婷婷亚洲成人福利在线-欧美日韩在线观看免费-国产99久久久久久免费看-国产欧美在线一区二区三区-欧美精品一区二区三区免费观看-国内精品99亚洲免费高清

 

作者： Niels M. B. Smeets,a   Mathew Patenaude,a   Dennis Kinio,a   Francis M. Yavitt,a   Emilia Bakaic,a   Fei-Chi Yang,b   Maikel Rheinstädterb and   Todd Hoarea   

a Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, Canada 

b Department of Physics and Astronomy, McMaster University, 1280 Main Street West, Hamilton, Canada

 

摘要：Injectable, in situ-gelling nanostructured hydrogels have been prepared from hydrazide and aldehyde-functionalized polymer precursors based on a copolymer of oligo(ethylene glycol) methacrylate (OEGMA) and an oligo(lactic acid) macromonomer (OLA) with varying lactic acid chain lengths. The resulting hydrogels contain a mix of chemical (hydrazone bond formation between hydrazide and aldehyde groups) and physical (hydrophobic interactions between OLA chains) cross-links which form competitively as a function of the OLA chain length and density. An increase in the OLA chain length and density results in the formation of more physical cross-links and fewer chemical cross-links. Tuning the relative prevalence of physical and chemical cross-link formation facilitated largely independent tuning of gel mechanics relative to gel swelling and degradation. Small-angle neutron scattering of these OLA-containing hydrogels reveals a microstructure consisting of associative hydrophobic domains, based on an increased scattering intensity and decreased blob size relative to that observed for POEGMA hydrogels prepared without the OLA co-monomer. The presence of hydrophobic OLA domains increases the uptake and slows the release of bovine serum albumin, a protein well-known to associate with hydrophobic domains. Coupled with the observed cytocompatibility of the reactive precursor polymers used to prepare the hydrogels, we anticipate significant potential applications of these hydrogels for the prolonged release of hydrophobic cargoes.